Increased contractility of cardiomyocytes from copper-deficient rats is associated with up-regulation of cardiac insulin-like growth factor-I receptor
نویسندگان
چکیده
1 Division of Pharmaceutical Sciences & Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071 2 Department of Pharmacology, Physiology and Therapeutics, School of Medicine, University of North Dakota, Grand Forks, ND 58202 3 U.S. Department of Agriculture, Agricultural Research Service***, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202
منابع مشابه
Increased contractility of cardiomyocytes from copper-deficient rats is associated with upregulation of cardiac IGF-I receptor.
Hearts from severely Cu-deficient rats show a variety of pathological defects, including hypertrophy and, in intact hearts, depression of contractile function. Paradoxically, isolated cardiomyocytes from these rats exhibit enhanced contractile properties. Because hypertrophy and enhanced contractility observed with other pathologies are associated with elevation of insulin-like growth factor-I ...
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